| 1876. 11. 13 | Founded as Governmental Lifesaving Clinic |
| 1894 | Renamed as Pusan Public Hospital |
| 1907. 12. 10 | Renamed as Pusan Settlement Corporation Hospital |
| 1914. 04. 01 | Renamed as Pusan Provincial Hospital |
| 1947. 07. 04 | Renamed as Pusan Municipal Hospital |
| 1956. 11. 01 | Reorganized as the Affiliated Hospital to the College of Medicine, Pusan National University |
| 1988. 02. 24 | Renamed as Pusan National University Hospital |
| 1994. 05. 20 | Reorganized as a Governmental Special Corporation |
| 1995. 09. 12 | Adopting Hospital Identity Program (HIP) |
| 1995. 12. | Designated as Regional Emergency Medical Center covering Pusan and Kyungnam areas |
| 1996. 02. 09 | Forwarded Order Communication System (OCS) |
| 1996. 05. 01 | Opened Health Promotion Center |
| 1996. 10. 28 | Started Construction of Regional Emergency Medical Center |
| 1998. 02. 05 | Started Operating the 1st Step of OCS |
| 2000. 12. 01 | Clinic for foreigners opened |
| 2001. 02. 19 | Home Nurse System introduced |
| 2001. 07. 01 | Hospital mascot announced |
| 2001. 12. 12 | Emergency Medical Center for the Busan area opened |
| 2002. 02. 05 | Cooperative medical examination and treatment with Busan Medical Center began |
| 2003. 01. 20 | Cardiovascular Angiographic Room opened |
| 2003. 02. 05 | Hematopoietic Stem Cell Transplantation Center opened |
| 2003. 04. 15 | Gastroenterology Center opened |
| 2003. 10. 23 | Gamma Knife Center opened |
| 2004. 09. 15 | Construction of medical and dental schools in the second campus of Pusan National University started |
| 2004. 10. 15 | Samji Library opened in the hospital. |
| 2004. 10. 19 | Automatic medical fee receivers and prescription issuers installed |
| 2004. 11. 25 | Ami Volunteer Service Corps received "Asan Grand Prize." |
| 2004. 12. 01 | PACS introduced |
